At that time there was not sufficient information to establish EARs and RDAs for pantothenic acid.
Institute of Medicine updated Estimated Average Requirements (EARs) and Recommended Dietary Allowances (RDAs) for B vitamins in 1998. As such, deficiencies in pantothenic acid may have numerous wide-ranging effects. Since pantothenic acid participates in a wide array of key biological roles, it is essential to all forms of life. Pantothenic acid in the form of CoA is also required for acylation and acetylation, which, for example, are involved in signal transduction and enzyme activation and deactivation, respectively. CoA is incidentally also required in the formation of ACP, which is also required for fatty acid synthesis in addition to CoA. CoA is also important in the biosynthesis of many important compounds such as fatty acids, cholesterol, and acetylcholine. CoA is important in energy metabolism for pyruvate to enter the tricarboxylic acid cycle (TCA cycle) as acetyl-CoA, and for α-ketoglutarate to be transformed to succinyl-CoA in the cycle. Coenzyme A may act as an acyl group carrier to form acetyl-CoA and other related compounds this is a way to transport carbon atoms within the cell.
Pantothenic acid is used in the synthesis of coenzyme A (CoA). The levorotatory (L) form may antagonize the effects of the dextrorotatory isomer. Only the dextrorotatory (D) isomer of pantothenic acid possesses biologic activity.
0 kommentar(er)
